Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities
نویسندگان
چکیده
Two flavones, ladanein and 6-hydroxy-5,7,4'-trimethoxyflavone and one labdane-type diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their (1)H and (13)C-NMR data, EI mass and UV spectral data. The compounds have been subjected to antimicrobial, antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidants compared with the isolated diterpene.
منابع مشابه
Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities
Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The co...
متن کاملLabdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities
Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The co...
متن کاملIridoid and Furanolabdane -Type Diterpene Glycosides from Rhizomes of Eremostachys azerbaijanica Rech. f.
Background and objectives: The rhizomes of Eremostachys azerbaijanica Rech. f.,as an indigenous plant in East Azerbaijan province of Iran, were studied for isolation and identification of possible phytoconstituents. Methods: The air- dried and ground rhizomes were extracted with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet appara...
متن کاملFlavonoid Constituents in Some Species of Salvia L. (Lamiaceae) in Iran
Eight Salvia L. species including S. spinosa L., S. reuterana Boiss., S. macrosiphon Boiss., S. syriaca L., S. nemorosa L., S. virgata Jacq., S. sharifii Rech. f. & Esfand. and S. mirzayanii Rech. f. & Esfand. were studied for flavonoid compounds. These constituents were analyzed using two-dimensional maps on silica gel 60F thin layer chromatography. The flavonoid compounds of each species were...
متن کاملNew diterpenoids from the aerial parts of Salvia reuterana
The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β,14α-dihydroxy-15-acetoxysclareol (1), and 14α,15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly...
متن کامل